Peptide Organic Chemist (Department of Machine Biology)
University of Pennsylvania

Peptide Organic Chemist (Department of Machine Biology)

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

COVID-19 vaccination or a University authorized exemption is a requirement for all positions at the University of Pennsylvania. For more information about Penn's vaccine requirements, visit the Penn COVID-19 Response website for the latest information.

Posted Job Title
Peptide Organic Chemist (Department of Machine Biology)

Job Profile Title
Research Specialist D

Job Description Summary
The candidate will initiate, contribute, and manage development of multiple projects and study protocols at direction of Principal Investigator. Leads research team to design and conduct qualitative research, instrument development projects which includes proposal development, research design, data collection, qualitative analyses, and report writing, to name a few. Develops literature, reports, grants, manuscripts, and publications to drive funding opportunities. Develops relationships with existing and potential funders, research partners, research sites, regulatory offices, and affiliated organizations as part of stakeholder management. Responsible to train and supervise staff, interface with existing postdoctoral fellows, staff members, and students in the laboratory. Develop and implement all safety procedures in the lab including drafting and implementing new SOPs and protocols for general laboratory practices, in compliance with Safety regulations. Close partnership with Principal Investigator to ensure success of all research in the lab.

Job Description

The candidate will initiate, contribute, and manage development of multiple projects and study protocols at direction of Principal Investigator. Leads research team to design and conduct qualitative research, instrument development projects which includes proposal development, research design, data collection, qualitative analyses, and report writing, to name a few. Develops literature, reports, grants, manuscripts, and publications to drive funding opportunities. Develops relationships with existing and potential funders, research partners, research sites, regulatory offices, and affiliated organizations as part of stakeholder management. Responsible to train and supervise staff, interface with existing postdoctoral fellows, staff members, and students in the laboratory. Develop and implement all safety procedures in the lab including drafting and implementing new SOPs and protocols for general laboratory practices, in compliance with Safety regulations. Close partnership with Principal Investigator to ensure success of all research in the lab.

The candidate will be responsible for the following work:

• Perform experiments related to organic synthesis, peptide synthesis, and post-synthesis modification in peptides and derivatives, along with their characterization, purification, and basic microbiology and cell culture assays to assess biological activities.
• Design and synthesize peptide therapeutics.
• Work alongside computational members to design, discovery, and optimize peptide therapeutics.
• Learn all assays currently available in the wet lab, perform experiments in facilities, and assist with animal models to determine the anti-infective activity of therapeutic peptides.
• Mentor and assist other lab members as needed.
• Organize and develop experiments, maintain equipment and workstations, and update inventory as needed.
• Leadership, upkeeping, and maintenance of state-of-the-art peptide lab.
• Extensive expertise in data analysis and manuscript preparation.
• Expertise in grant writing and fundraising experience.

The candidate must have experience with:

• Peptide design and synthesis.
• Chemistry techniques (e.g., handling solvents and reagents, purification of solvents, synthesis and extraction of organic molecules, in solution and solid-phase peptide synthesis, cyclization and conjugation reactions, compounds purification and characterization, including nuclear magnetic resonance, liquid chromatography, gas phase chromatography, mass spectrometry, infrared spectroscopy, thin layer chromatography, etc.).
• Biophysics techniques (e.g., preparation of vesicles and micelles, perform leakage assays, isothermal titration calorimetry, surface plasmon resonance, circular dichroism, and oriented circular dichroism, among others).
• Microscopy expertise (e.g., confocal, optical, and fluorescent microscopes, etc.).
• Expertise using graphical design tools (e.g., ChemDraw and Adobe Illustrator or equivalent software).
• Lab management.

In addition, the candidate will be responsible for leading and conducting a wide range of biological tests using antimicrobial compounds. Other techniques necessary for this position include proficiency with sterilization techniques; microdilution method for determining minimal inhibitory concentrations; bactericidal, cytotoxicity, and hemolytic assessments against eukaryotic cells; mechanisms of action experiments (DNA binding, Laurdan, NPN uptake, OPNG, DiSC3-5 and other mechanism of action assays); multiplex ELISA assays; resistance development assays; and synergy assays.

Total Base Pay Range for this position is: $51,824 - $91,232.

Qualifications:

Masters Degree required, PhD strongly preferred and 3-5 years of experience or equivalent combination of education and experience required.

This position is contingent upon funding.

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$51,824.00 - $78,096.00
Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile.

Affirmative Action Statement
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements
Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits

• Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
  
• Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
  
• Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
  
• Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family—whatever your personal needs may be.
  
• Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
  
• Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
  
• Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
  
• University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement—and you and your family can enjoy many of these activities for free.
  
• Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
  
• Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
  
• Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
  
• Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.
  

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To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay


To apply, visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/Medical-School-Johnson-Pavilion---3rd-Floor/Peptide-Organic-Chemist--Department-of-Translational-Neuroscience-_JR00060124-1







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