Senior Scientist, Bioconjugation
AstraZeneca

Senior Scientist, Bioconjugation

Gaithersburg, MD

Are you ready to take our leading Oncology pipeline to the next level? As a Senior Scientist in Bioconjugation, you will play a pivotal role in advancing the development of cutting-edge antibody drug conjugates across various therapeutic domains. We are seeking a driven and proficient Senior Scientist, Bioconjugation with a strong foundation in drug discovery. This role offers an exciting opportunity to spearhead and contribute to multifaceted drug development endeavors.

Typical Accountabilities:

As a Senior Scientist, you will execute conjugation, purification, and characterization of ADCs, ranging from milligram to gram quantities, utilizing a variety of established methodologies. You will innovate and optimize novel conjugation techniques to enhance ADC properties and coordinate and streamline conjugation workflows within a collaborative team environment. You will also engage in cross-functional collaboration with diverse scientific teams spanning therapeutic areas, chemistry, and process development to drive research progress and foster technological breakthroughs. Leading and overseeing laboratory operations, including equipment maintenance and adherence to safety protocols, will also be part of your responsibilities.

Essential Skills/Experience:

• PhD in Organic Chemistry, Chemical Biology, Biochemistry, or related field with 0-3 yrs relevant experience OR Master's degree in Organic Chemistry, Chemical Biology, Biochemistry, or related field with at least 7 years of relevant experience.
• Extensive hands-on expertise in designing and generating antibody drug conjugates.
• Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography-Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC.
• Hands-on experience in protein purification using HIC, IEX, SEC, and affinity chromatography, preferably with GE AKTA FPLC.
• Consistent record of working autonomously, adeptly planning and organizing tasks, and prioritizing activities to meet project deadlines.
• Demonstrated skill in protocol optimization and troubleshooting with a problem solving approach, along with meticulous record-keeping in laboratory notebooks.
• Track record of scientific innovation showcased through publications, patents, and presentations at scientific conferences.
• Exceptional written and verbal communication skills, with the ability to convey complex scientific data effectively to cross-functional teams and senior management.

Desirable Skills/Experience:

• Experience in protein engineering and production would be advantageous.
• Familiarity with coordinating activities with Contract Research Organizations (CROs).

About Our Gaithersburg Oncology Hub

The Gaithersburg site (https://www.youtube.com/watch?v=GOvxXGjBd1w) employs more than 3,500 experts in our field and is only a short drive from Washington, DC. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg campus offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria, game rooms, community garden and much more.

At AstraZeneca's Oncology R&D department, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are a science, leading and decisive Oncology enterprise united in our vision to eliminate cancer as a cause of death. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next.

We believe in growing together and providing a place where everyone can have a voice. Ambitious and collaborative, we're optimistic in our ability to be resilient and work together towards a cure.

Ready to make a difference? Apply today and join us in our mission to eliminate cancer as a cause of death!

If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: November 1, 2024

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

The annual base pay (or hourly rate of compensation) for this position ranges from $105,875 to $158,812. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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